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Auteur Benatru I
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Association of Parkinson's disease and its subtypes with agricultural pesticide exposures in men: a case-control study in France / Moisan F in Environmental health perspectives [Environ Health Perspect], Vol. 123, N° 11 ([01/11/2015])
Titre : Association of Parkinson's disease and its subtypes with agricultural pesticide exposures in men: a case-control study in France Type de document : Article scientifique Auteur(s) : Moisan F ; Spinosi J ; Delabre L ; Gourlet V ; Mazurie JL ; Benatru I ; Goldberg M ; Weisskopf MG ; Imbernon E ; Tzourio C ; Elbaz A Appartenance auteur(s) InVS DST Année de publication : 2015 Article en page(s) : 1123-9 Langues : Anglais (eng)
in Environmental health perspectives [Environ Health Perspect] > Vol. 123, N° 11 [01/11/2015] . - 1123-9
Mots-clés : Maladie Parkinson ; Pesticide ; Exposition professionnelle ; Exploitant agricole ; Enquête cas témoin ; France Résumé : Background: pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes.
Objectives: we examined quantitative aspects of occupational pesticide exposure associated with PD and investigated whether associations were similar across PD subtypes.
Methods: as part of a French population-based case-control study including men enrolled in the health insurance plan for farmers and agricultural workers, cases with clinically confirmed PD were identified through antiparkinsonian drug claims. Two controls were matched to each case. Using a comprehensive occupational questionnaire, we computed indicators for different dimensions of exposure (duration, cumulative exposure, intensity). We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CI) among exposed male farmers (133 cases, 298 controls). We examined the relation between pesticides and PD subtypes (tremor dominant/non-tremor dominant) using polytomous logistic regression.
Results: there appeared to be a stronger association with intensity than duration of pesticide exposure based on separate models and a synergistic interaction between duration and intensity (p-interaction = 0.04). High intensity exposure to insecticides was positively associated with PD among those with low intensity exposure to fungicides and vice versa, suggesting independent effects. Pesticide exposure in farms specialized in vineyards was associated with PD (OR = 2.56; 95% CI: 1.31, 4.98). The association with intensity of pesticide use was stronger, although not significantly (p-heterogeneity = 0.60), for tremor dominant (p--trend < 0.01) than for non-tremor dominant PD (p--trend = 0.24).
Conclusions: this study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor dominant PD in men, the most typical PD presentation.
PMID Pubmed : Pubmed : 25815770 Lien externe DOI : DOI : 10.1289/ehp.1307970 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=12498[article]Impact of recommendations on the initial therapy of Parkinson’s disease: a population-based study in France / Fayard C in Parkinsonism and Related Disorders [Parkinsonism Relat Disord], Vol. 17, N° 7 ([01/08/2011])
Titre : Impact of recommendations on the initial therapy of Parkinson’s disease: a population-based study in France Type de document : Article scientifique Auteur(s) : Fayard C ; Bonaventure A ; Benatru I ; Roze E ; Dumurgier J ; Moisan F ; Soumare A ; Houssinot J ; Dupupet JL ; Mazurie JL ; Balaboi I ; Houeto JL ; Krim E ; Ranoux D ; Goldberg M ; Imbernon E ; Moreau T ; Giroud M ; Tzourio C ; Elbaz A Appartenance auteur(s) InVS DST Année de publication : 2011 Article en page(s) : 543-6 Langues : Anglais (eng)
in Parkinsonism and Related Disorders [Parkinsonism Relat Disord] > Vol. 17, N° 7 [01/08/2011] . - 543-6
Mots-clés : Maladie Parkinson ; Thérapeutique ; Complication ; Conférence consensus ; Impact sanitaire ; Recommandation ; Pratique médicale ; Enquête épidémiologique ; France Résumé : Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n = 49) and levodopa in patients ≥70 years (n = 133). Agreement with the recommendations increased after 2000 (66.0%) compared to before (46.3%, p = 0.025). For patients <60 years, agreement increased (64.0% vs 20.2%, p = 0.017) while it remained stable (66.4% vs 70.6%, p = 0.73) in patients ≥70 years. The publication of recommendations has influenced initial treatment choices for PD in France. PMID Pubmed : Pubmed : 21612970 Lien externe DOI : DOI : 10.1016/j.parkreldis.2011.04.020 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=9588[article]