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A 2-year study on cytomegalovirus infection during pregnancy in a French hospital / Picone O in British Journal of Obstetrics and Gynaecology [BJOG], Vol. 116, N° 6 (05/2009)

[article]  inBritish Journal of Obstetrics and Gynaecology [BJOG] > Vol. 116, N° 6 (05/2009) . - 818-23 Titre : A 2-year study on cytomegalovirus infection during pregnancy in a French hospital Type de document : Article scientifique Auteur(s) : Picone O ; Vauloup Fellous C ; Cordier AG ; Parent du Chatelet I ; Senat MV ; Frydman R ; Grangeot Keros L Appartenance auteur(s) InVS DMI Année de publication : 2009 Article en page(s) : 818-23 Langues : Anglais (eng) Mots-clés : Cytomégalovirus ; Grossesse ; Gestation [pathologie] ; Transmission verticale ; Nouveau né ; Diagnostic prénatal ; Dépistage anténatal ; France Résumé : OBJECTIVES: To evaluate the proportion of pregnant women agreeing to cytomegalovirus (CMV) serologic screening. To collect data on CMV infection during pregnancy. DESIGN: Prospective study. SETTING: During two years, all pregnant women were informed on CMV infection. If the patient agreed, serological testing was performed around 12 weeks of gestation (WG) and, if negative, redone around 36 WG. POPULATION: Four thousand two hundred and eighty-seven pregnant women followed from 12 weeks to delivery. METHODS: If the first CMV serologic test was negative, detailed hygiene information was given to the parents. Diagnosis of primary infection was based on the detection of CMV-G, CMV-M and low CMV-G avidity index. When maternal infection was confirmed, diagnosis of CMV congenital infection was done in the newborns by urine culture within the three days following birth. Crude infection-rate data consisted of the number of CMV infection cases and person-time units for both exposed to hygiene CMV information (12 to 36 WG) and unexposed pregnant women (first 12 WG). MAIN OUTCOME MEASURES: Rate of CMV seropositive and seronegative women. Rate of women agreeing for screening. Rate of primary infection. Rate of seroconversion. Number of CMV-infected newborns. RESULTS: Among the 4287 women followed, 3792 were either seronegative or with an unknown immune status. 96.7% out of them agreed for screening. 53.2% were initially CMV-specific IgG negative. Primary infection was detected in nine women between 0 and 12 WG (0.46%) and seroconversion was diagnosed in five women between 12 and 36 WG (0.26%) (mid P = 0.02, 95% CI [1.07-13.6]). CONCLUSIONS: If clear information on CMV infection during pregnancy is given, patients frequently agree to screening. The rate of seroconversion after information, observed in this study, is low after counselling.(R.A.) PMID Pubmed : Pubmed : 19432571 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=1366 [article]

Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy ? Results of a 3-year prospective study in a French hospital / Vauloup Fellous C in Journal of Clinical Virology [J Clin Virol], Vol. 46, N° Suppl 4 (10/2009)

[article]  inJournal of Clinical Virology [J Clin Virol] > Vol. 46, N° Suppl 4 (10/2009) . - S49-53 Titre : Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy ? Results of a 3-year prospective study in a French hospital Type de document : Article scientifique Auteur(s) : Vauloup Fellous C ; Picone O ; Cordier AG ; Parent du Chatelet I ; Senat MV ; Frydman R ; Grangeot Keros L Appartenance auteur(s) InVS DMI Année de publication : 2009 Article en page(s) : S49-53 Langues : Anglais (eng) Mots-clés : Cytomégalovirus ; Maladie congénitale ; Grossesse ; Test dépistage ; Examen sérologique ; Enquête cohorte Résumé : BACKGROUND: Cytomegalovirus (CMV) is the most frequent cause of congenital viral infection in developed countries. OBJECTIVES: The objective of this study was to evaluate the impact of our prenatal CMV infection screening and counseling policy. STUDY DESIGN: Since 2005, all pregnant women in our obstetric center have been informed about CMV infection, and if they agree, given a serological test at around 12 weeks of gestation (WG). If this first test is negative, the women and their partners are given hygiene counseling on how to prevent CMV infection, and a second test is performed at around 36 WG. RESULTS: Among the 5312 women who had an unknown immune status, or were known to be seronegative when they had their first visit to our center for their current pregnancy, 97.4% agreed to CMV screening. Primary infection was detected in 11 women between 0 and 12 WG (0.42%), and seroconversion was diagnosed in five women between 12 and 36 WG (0.19%). CONCLUSIONS: These results suggest that if clear information is given on CMV infection during pregnancy, the rate of seroconversion is lower following counseling than before counseling. PMID Pubmed : Pubmed : 19811947 Lien externe DOI : DOI : 10.1016/j.jcv.2009.09.003 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=876 [article]