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Effectiveness of HPV vaccination on prevalence of vaccine genotypes in young sexually active women in France / Heard I in The Journal of infectious diseases [J Infect Dis], In Press ([01/12/2016])
Titre : Effectiveness of HPV vaccination on prevalence of vaccine genotypes in young sexually active women in France Type de document : Article scientifique Auteur(s) : Heard I ; Tondeur L ; Arowas L ; Demazoin M ; Falguieres M ; Parent du Chatelet I ; groupe CHlaHPV Appartenance auteur(s) InVS DMI Année de publication : 2016 Article en page(s) : 24 p. Langues : Anglais (eng)
in The Journal of infectious diseases [J Infect Dis] > In Press [01/12/2016] . - 24 p.
Résumé : Background: effectiveness of human papillomavirus (HPV) vaccines in the context of both guidelines which recommend vaccination at 14 years and modest vaccine coverage is poorly documented.
Method: residual specimens from females aged under 25 years undergoing chlamydia testing were collected, together with demographic, sexual behaviour and vaccine status data. HPV genotypes were determined using the PapilloCheck® test system. We compared vaccine type (VT, types 6,11,16,18) prevalence according to vaccination status and identified factors associated with VT prevalence.
Results: of 3736 eligible samples, 822 were from vaccinated women according to immunisation record, 1021 from women self-reporting vaccination and 1893 from unvaccinated women. Adjusted vaccine effectiveness for confirmed vaccinated compared with unvaccinated women was 95.93% (95%CI,90.22-98.32) against VT HPV and 38.37% (95%CI,12.68-56.51) against cross reactive genotypes (HPV31,33,45), respectively. VT HPV prevalence was significantly lower (.61%) among confirmed-vaccinated than among those who self-reported vaccination or unvaccinated women (1.76% and 15.0%, respectively). Factors associated with prevalent VT in multivariable analysis were vaccine status, positive C. trachomatis and ≥4 partners in the preceding year.
Conclusion: our study demonstrates evidence of high effectiveness of HPV prophylactic vaccines at an individual level, supporting that wider implementation will help to reduce cervical cancer and precursors incidence.
PMID Pubmed : Pubmed : 28011911 Lien externe DOI : DOI : 10.1093/infdis/jiw639 Corpus : Santé publique France Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=13258[article]