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Auteur Chidiac C
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Complications and factors associated with severity of influenza in hospitalized children and adults during the pandemic wave of A(H1N1)pdm2009 infections.The Fluco French cohort / Ploin D in Journal of Clinical Virology [J Clin Virol], Vol. 58, N° 1 ([02/09/2013])
Titre : Complications and factors associated with severity of influenza in hospitalized children and adults during the pandemic wave of A(H1N1)pdm2009 infections.The Fluco French cohort Type de document : Article scientifique Auteur(s) : Ploin D ; Chidiac C ; Carrat F ; Cohen B ; Javouhey E ; Mayaud C ; Desenclos JC ; Lina B ; Leport C ; Groupe de travail FLUCO Appartenance auteur(s) InVS DS Année de publication : 2013 Article en page(s) : 114-9 Langues : Anglais (eng)
in Journal of Clinical Virology [J Clin Virol] > Vol. 58, N° 1 [02/09/2013] . - 114-9
Mots-clés : Nouvelle grippe A (H1N1) ; Pandémie ; Complication ; Facteur risque ; Enquête cohorte ; France Résumé : Background - The emergence of novel A(H1N1)pdm2009 virus threatened to lead to frequent severe manifestations.
Objectives - To describe the clinical, virological, and biological characteristics of the disease and identify the factors associated with severe presentations.
Study design - This prospective multicenter study recruited consecutive hospitalized patients with confirmed A(H1N1)pdm2009 disease. Clinical, virological and biological assessments were carried out at inclusion and 30 days post-inclusion. Disease manifestations were assessed by an adjudication committee using pre-identified definitions of complications and severity scores.
Results - The study analyzed from November 30th, 2009 to February 8th, 2010, 40 hospitalized patients, 21 children and 19 adults. Eighteen (45%) were considered to have severe presentations. Except age, main characteristics in children and adults did not differ. The majority (18/21) of children and all adults had a respiratory presentation; extra-respiratory manifestations tended to be more frequent in children (12 vs. 6, P = 0.10). Two children against 5 adults presented acute respiratory distress syndrome (ARDS, P = 0.23), but more children suffered respiratory failure (7 vs. 1, P = 0.046) without ARDS. At day 30, one death had occurred in each group. The main factor associated with non-severe presentation was an early (<48 h) implementation of oseltamivir treatment (P = 0.038).
Conclusions - Although the study failed to achieve its main objective, due mainly to the difficulty of carrying a study of this nature in the midst of a pandemic, it allowed the description of a panel of unusual and complicated forms and confirmed the added value of early oseltamivir treatment in limiting severity in hospitalized children and adults. (R.A.)
PMID Pubmed : Pubmed : 23829965 Lien externe DOI : DOI : http://dx.doi.org/10.1016/j.jcv.2013.05.025 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=11592[article]Factors associated with hospital mortality in community-acquired legionellosis in France / Chidiac C in The European respiratory journal [Eur Respir J], Vol. 39, N° 4 (Avril 2012)
Titre : Factors associated with hospital mortality in community-acquired legionellosis in France Type de document : Article scientifique Auteur(s) : Chidiac C ; Che D ; Pires Cronenberger S ; Jarraud S ; Campese C ; Bissery A ; Weinbreck P ; Brun Buisson C ; Sollet JP ; Ecochard R ; Desenclos JC ; Etienne J ; Vanhems P ; French Legionnaires' Disease Study Group Appartenance auteur(s) InVS DMI ; DS Année de publication : 2012 Article en page(s) : 963-70 Langues : Anglais (eng)
in The European respiratory journal [Eur Respir J] > Vol. 39, N° 4 (Avril 2012) . - 963-70
Mots-clés : Légionellose ; Mortalité ; Hôpital ; Infection nosocomiale ; Facteur risque ; France Résumé : The aims of this work are to describe the clinical, biological and radiological features of community-acquired (CA) Legionnaires' disease (LD) and identify the predictors of mortality in hospitalised patients.Demographic data, risk factors, clinical, and biological features, medical management, complications and outcome from 540 hospitalised patients with confirmed CA LD were prospectively recorded.8.1% of patients (44/540) died. The predictors of survival after Kaplan-Meier analysis were male gender (P=.01), age <60 years (P=.02), general symptoms (P=.006), intensive care unit (ICU) stay (P<.001), and class II-III pneumonia severity index score (P=.004). Six predictors of death were identified by multivariate analysis: age (per 10-year increments) (relative hazard (RH), 1.50; 95% confidence interval [95% CI], 1.21-1.87), female gender (RH, 2.00; 95% CI, 1.08-3.69), ICU admission (RH, 3.31; 95% CI, 1.67-6.56), renal failure (RH, 2.73; 95% CI, 1.42-5.27), corticosteroid therapy (RH, 2.54; 95% CI, 1.04-6.20) and C-reactive protein (CRP) >500 mg·L(-1) (RH, 2.14; 95% CI, 1.02-4.48). Appropriate antibiotic therapy was prescribed for 76.3% (292/412) of patients after admission and for 99.6% (537/538) of patients after diagnosis confirmation.In conclusion, female gender, age, ICU stay, renal failure, corticosteroid treatment, and increased level of CRP are significant risk factors for mortality in CA LD. (R.A.) PMID Pubmed : Pubmed : 22005914 Lien externe DOI : DOI : 10.1183/09031936.00076911 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=10010[article]Suspected SARS patients hospitalised in French isolation units during the early SARS epidemic: The French experience / Issartel B in Eurosurveillance. European communicable disease quarterly [Euro Surveill (quaterly)], Vol. 10, N° 1-3 (2005)
Titre : Suspected SARS patients hospitalised in French isolation units during the early SARS epidemic: The French experience Type de document : Article scientifique Auteur(s) : Issartel B ; Lesens O ; Chidiac C ; Mouton Y ; Christmann D ; Peyramond D Année de publication : 2005 Article en page(s) : 39-3 Langues : Anglais (eng)
in Eurosurveillance. European communicable disease quarterly [Euro Surveill (quaterly)] > Vol. 10, N° 1-3 (2005) . - 39-3
Mots-clés : Quarantaine ; Epidémie ; Surveillance épidémiologique ; Gestion risque ; Alerte sanitaire ; Virus ; Prise charge médicosociale ; Hospitalisation ; France ; Pneumonie ; Prévention maladie transmissible ; Transmission Mots-clés : APPAREIL RESPIRATOIRE [PATHOLOGIE] Résumé : During the SARS epidemic, many patients were screened according to WHO criteria but never went on to develop SARS. In May 2003, early in the epidemic, we conducted a retrospective study to describe suspected SARS patients hospitalised in France and compared them with documented cases of patients with SARS to evaluate the screening strategy. A total of 117 patients were studied. Only 3.4% had been in close contact with a SARS patient but 73.5% came from an affected area. 67.5% had fever and respiratory symptoms on their admission to hospital. 49.6% had fever and non specific symptoms. Clinical symptoms that were significantly more common among patients with SARS were fever, myalgia, dyspnoea, and nausea or vomiting. Presumed viral fever and respiratory tract infection were the most common diagnosis. Symptoms cannot be distinguished from an early stage of SARS confirming the usefulness of the WHO case definitions in isolation decision to avoid further transmission. Corpus : Production scientifique InVS Lien(s) externe(s) : http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=524 Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=3020[article]
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