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Auteur Vonk J
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Ajouter le résultat dans votre panier Affiner la rechercheAcute effects of ozone on mortality from the "air pollution and health: a European approach" project / Gryparis A in American Journal of Respiratory and Critical Care Medicine [Am J Respir Crit Care Med], Vol. 170, N° 10 (11/2004)
Titre : Acute effects of ozone on mortality from the "air pollution and health: a European approach" project Type de document : Article scientifique Auteur(s) : Gryparis A ; Forsberg B ; Katsouyanni K ; Analitis A ; Touloumi G ; Schwartz J ; Samoli E ; Medina S ; Anderson HR ; Niciu EM ; Wichmann HE ; Kriz B ; Kosnik M ; Skorkovsky J ; Vonk J ; Dortbudak Z Appartenance auteur(s) InVS DSE Année de publication : 2004 Article en page(s) : 1080-7 Langues : Anglais (eng)
in American Journal of Respiratory and Critical Care Medicine [Am J Respir Crit Care Med] > Vol. 170, N° 10 (11/2004) . - 1080-7Mots-clés : Pollution atmosphérique ; Milieu urbain ; Ozone ; Mortalité ; Cause décès ; Etude comparée ; Europe ; Risque relatif ; Enquête rétrospective ; Evaluation risque Mots-clés : APPAREIL CIRCULATOIRE [PATHOLOGIE] APPAREIL RESPIRATOIRE [PATHOLOGIE] Résumé : In the Air Pollution and Health: A European Approach (APHEA2) project, the effects of ambient ozone concentrations on mortality were investigated. Data were collected on daily ozone concentrations, the daily number of deaths, confounders, and potential effect modifiers from 23 cities/areas for at least 3 years since 1990. Effect estimates were obtained for each city with city-specific models and were combined using second-stage regression models. No significant effects were observed during the cold half of the year. For the warm season, an increase in the 1-hour ozone concentration by 10 mug/m3 was associated with a 0.33% (95% confidence interval [CI], 0.17-0.52) increase in the total daily number of deaths, 0.45% (95% CI, 0.22-0.69) in the number of cardiovascular deaths, and 1.13% (95% CI, 0.62-1.48) in the number of respiratory deaths. The corresponding figures for the 8-hour ozone were similar. The associations with total mortality were independent of SO2 and particulate matter with aerodynamic diameter less than 10 mum (PM10) but were somewhat confounded by NO2 and CO. Individual city estimates were heterogeneous for total (a higher standardized mortality rate was associated with larger effects) and cardiovascular mortality (larger effects were observed in southern cities). The dose-response curve of ozone effects on total mortality during the summer did not deviate significantly from linearity. PMID Pubmed : Pubmed : 15282198 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=5681 [article]
Titre : Analysis of health outcome time series data in epidemiological studies Type de document : Article scientifique Auteur(s) : Touloumi G ; Atkinson R ; Le Tertre A ; Samoli E ; Schwartz J ; Schindler C ; Vonk J ; Rossi G ; Saez M ; Rabczenko D ; Katsouyanni K Appartenance auteur(s) InVS DSE Année de publication : 2004 Article en page(s) : 101-17 Langues : Anglais (eng)
in Environmetrics > Vol. 15 (2004) . - 101-17Mots-clés : Statistique Mots-clés : SERIE TEMPORELLE Résumé : Several recent studies have reported significant health effects of air pollution even at low levels of air pollutants. These studies have been criticized for the statistical methods and for inconsistency in results between cities. An important development in air pollution epidemiology has come from multicenter studies. Within the APHEA-2 project we have developed a statistical methodology to evaluate short-term health effects of air pollution using data from 30 cities across Europe. For the analysis, a hierarchical modelling approach was adopted and implemented in two stages: (a) data from each city were analyzed separately to allow for local differences, using generalized additive Poisson regression models; (b) city-specific effects estimates were regressed on city-specific covariates to obtain an overall estimate and to explore heterogeneity across cities. In order to illustrate our methodology we present results for PM10 effects. It was found that a 10 microg/m3 increase in PM10 or NO2 concentrations is associated with a 0.67% (95% CI: 0.50 to 0.90) and 0.33% (0.20 to 0.40) increase in total mortality, respectively. After mutual adjustment, the PM10 effect was reduced by 40% and that of NO2 by 20%, but both pooled estimates remained significant. Long-term mean NO2 concentrations act as an effect modifier for PM10 effects, even after adjustment for NO2 confounding effects. In the second stage we explored two different models for combining the adjusted for NO2, PM10 effects across cities: bivariate, which accounts for within-city correlation of PM10 and NO2; and univariate, which ignores this correlation. Both models gave broadly the same results Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=5662 [article]
Titre : Investigating the dose-response relation between air pollution and total mortality in the APHEA-2 multicity project Type de document : Article scientifique Auteur(s) : Samoli E ; Touloumi G ; Zanobetti A ; Le Tertre A ; Schindler C ; Atkinson R ; Vonk J ; Rossi G ; Saez M ; Rabczenko D ; Schwartz J ; Katsouyanni K Appartenance auteur(s) InVS DSE Année de publication : 2003 Article en page(s) : 977-82 Langues : Anglais (eng)
in Occupational and environmental medicine [Occup Environ Med] > Vol. 60, N° 12 (12/2003) . - 977-82Mots-clés : Pollution atmosphérique ; Europe ; Surveillance environnement ; Dioxyde azote ; Milieu urbain ; Mortalité ; Enquête épidémiologique ; Modèle Résumé : BACKGROUND: Several recent studies have reported significant health effects of air pollution even at low levels of air pollutants, but in most of these studies linear non-threshold relations were assumed. AIMS: To investigate the NO2 mortality dose-response association in nine cities participating in the APHEA-2 project using two different methods: the meta-smooth and the cubic spline method. METHODS: The meta-smooth method developed by Schwartz and Zanobetti is based on combining individual city non-parametric smooth curves; the cubic spline method developed within the APHEA-2 project combines individual city estimates of cubic spline shaped dose-response relations. The meta-smooth method is easier and faster to implement, but the cubic spline method is more flexible for further investigation of possible heterogeneity in the dose-response curves among cities. RESULTS: In the range of the pollutant common to all cities the two methods gave similar and comparable curves. Using the cubic spline method it was found that smoking prevalence acts as an effect modifier with larger NO2 effects on mortality at lower smoking prevalence. CONCLUSIONS: The NO2-mortality association in the cities included in the present analysis, could be adequately estimated using the linear model. However, investigation of the city specific dose-response curves should precede the application of linear models. PMID Pubmed : Pubmed : 14634192 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=5663 [article]
Titre : The association of daily sulfur dioxide air pollution levels with hospital admissions for cardiovascular diseases in Europe (The Aphea-II study) Type de document : Article scientifique Auteur(s) : Sunyer J ; Ballester F ; Le Tertre A ; Atkinson R ; Ayres JG ; Forastiere F ; Forsberg B ; Vonk J ; Bisanti L ; Tenias JM ; Medina S ; Schwartz J ; Katsouyanni K Appartenance auteur(s) InVS DSE Année de publication : 2003 Article en page(s) : 752-60 Langues : Anglais (eng)
in European heart journal [Eur Heart J] > Vol. 24, N° 8 (04/2003) . - 752-60Mots-clés : Adulte ; Pollution atmosphérique ; Accident cérébrovasculaire ; Europe ; Hospitalisation ; Ischémie ; Dioxyde soufre ; Entrée ; Motif hospitalisation ; Particule atmosphérique ; Surveillance environnement ; Analyse air Mots-clés : APPAREIL CIRCULATOIRE [PATHOLOGIE] IMPACT Résumé : The objective of this study is to assess the short-term effect of sulfur dioxide (SO(2)) air pollution levels on hospital admissions for cardiovascular diseases. Daily mean hospital admissions for cardiovascular diseases, ischemic heart diseases (IHDs), and stroke in seven European areas (the cities of Birmingham, London, Milan, Paris, Rome, and Stockholm, and in The Netherlands) participating in the multicenter European study of air pollution (Aphea-II), were measured. Time series analysis of daily hospital admission counts was performed using poison autoregressive models. A summary regression coefficient for all cities was provided. Daily numbers of all cardiovascular admissions except stroke, and particularly IHDs, rose significantly with an increase of daily SO(2)levels of the same day and day before. After adjusting for PM(10)(i.e. particles with size PMID Pubmed : Pubmed : 12713769 Corpus : Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=5694 [article]
