| Titre : | Herpes simplex encephalitis and management of acyclovir in encephalitis patients in France |
| Type de document : | Article scientifique |
| Auteur(s) : | Stahl JP ; Mailles A ; De Broucker T |
| Appartenance auteur(s) InVS | DMI |
| Année de publication : | 2012 |
| Article en page(s) : | 372-81 |
| Langues : | Anglais (eng) |
in Epidemiology and Infection [Epidemiol Infect] > Vol. 140, N° 2 [01/02/2012] . - 372-81| Mots-clés : | Encéphalite ; Herpès ; Virologie ; France
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| Résumé : | This study reports on the clinical profiles of herpes simplex encephalitis (HSE) case-patients and the management of acyclovir prescriptions. We designed a study on the causes of encephalitis in France in 2007. Case-patients fulfilling the inclusion criteria were enrolled in all the hospitals that volunteered to participate. Fifty-five of 253 enrolled case-patients were diagnosed with HSE. Three (5%) HSE patients died and 48 (89%) were discharged with persistent neurological symptoms. All HSE patients were prescribed acyclovir, 10 of whom had a 2-week course; 42 a 3-week course; two received incomplete courses; and one received two courses of 21 days each due to relapse. The acyclovir dosage was reported for 45 adult HSE patients, 25 (53%) of whom received 10 mg/kg t.i.d. and 22 (47%) received 15 mg/kg t.i.d. The mortality rate was low despite 49% of patients being admitted to intensive-care units. A high dose of acyclovir was not associated with a better outcome in HSE patients. Most patients had persisting symptoms on discharge suggesting neuropsychological rehabilitation is an important issue for survivors.
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| PMID Pubmed : | Pubmed : 21470440  |
| Lien externe DOI : | DOI : 10.1017/S0950268811000483 |
| Corpus : | Production scientifique InVS |
| Permalink : | http://opac.invs.sante.fr/index.php?lvl=notice_display&id=9405 |
Ajouter le résultat dans votre panierHerpes simplex encephalitis and management of acyclovir in encephalitis patients in France / Stahl JP in Epidemiology and Infection [Epidemiol Infect], Vol. 140, N° 2 ([01/02/2012])
