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Surgical mask to prevent influenza transmission in households: a cluster randomized trial / Canini L in PloS one [PLoS One], Vol. 5, N° 11 (11/2010)
Titre : Surgical mask to prevent influenza transmission in households: a cluster randomized trial Type de document : Article scientifique Auteur(s) : Canini L ; Andreoletti L ; Ferrari P ; D'Angelo R ; Blanchon T ; Lemaitre M ; Filleul L ; Ferry JP ; Desmaizieres M ; Smadja S ; Valleron AJ ; Carrat F Appartenance auteur(s) InVS Cire Aquitaine Année de publication : 2010 Article en page(s) : 6 p. Langues : Anglais (eng)
in PloS one [PLoS One] > Vol. 5, N° 11 (11/2010) . - 6 p.
Mots-clés : Masque ; Grippe ; France ; Prévention maladie transmissible ; Randomisation ; Pandémie Résumé : BACKGROUND: Facemasks and respirators have been stockpiled during pandemic preparedness. However, data on their effectiveness for limiting transmission are scarce. We evaluated the effectiveness of facemask use by index cases for limiting influenza transmission by large droplets produced during coughing in households. METHODOLOGY AND PRINCIPAL FINDINGS: A cluster randomized intervention trial was conducted in France during the 2008-2009 influenza season. Households were recruited during a medical visit of a household member with a positive rapid influenza A test and symptoms lasting less than 48 hours. Households were randomized either to the mask or control group for 7 days. In the intervention arm, the index case had to wear a surgical mask from the medical visit and for a period of 5 days. The trial was initially intended to include 372 households but was prematurely interrupted after the inclusion of 105 households (306 contacts) following the advice of an independent steering committee. We used generalized estimating equations to test the association between the intervention and the proportion of household contacts who developed an influenza-like illness during the 7 days following the inclusion. Influenza-like illness was reported in 24/148 (16.2%) of the contacts in the intervention arm and in 25/158 (15.8%) of the contacts in the control arm and the difference between arms was 0.40% (95%CI: -10% to 11%, P¿=¿1.00). We observed a good adherence to the intervention. In various sensitivity analyses, we did not identify any trend in the results suggesting effectiveness of facemasks. CONCLUSION: This study should be interpreted with caution since the lack of statistical power prevents us to draw formal conclusion regarding effectiveness of facemasks in the context of a seasonal epidemic. (R.A.) PMID Pubmed : Pubmed : 21103330 Lien externe DOI : DOI : 10.1371/journal.pone.0013998 Corpus : CIRE/Production scientifique InVS Permalink : http://opac.invs.sante.fr/index.php?lvl=notice_display&id=466[article]