| Titre : | Pandemic influenza due to pH1N1/2009 virus: estimation of infection burden in Reunion Island through a prospective serosurvey, austral winter 2009 |
| Type de document : | Article scientifique |
| Auteur(s) : | Dellagi K ; Rollot O ; Temmam S ; Salez N ; Guernier V ; Pascalis H ; Gerardin P ; Fianu A ; Lapidus N ; Naty N ; Tortosa P ; Jaffar Bandjee MC ; Filleul L ; Flahault A ; Carrat F ; Favier F ; de Lamballerie X |
| Appartenance auteur(s) InVS | Cire Océan Indien |
| Année de publication : | 2011 |
| Article en page(s) : | e25738 |
| Langues : | Anglais (eng) |
in PloS one [PLoS One] > Vol. 6, N° 9 [01/09/2011] . - e25738| Mots-clés : | Nouvelle grippe A (H1N1) ; Pandémie ; Etude prospective ; Séroprévalence ; Ile de la Réunion
|
| Résumé : | Background. To date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season.
Methodology/Principal Findings. A serosurvey was conducted during the 2009 austral winter, in the frame of a prospective population study. Pairs of sera were collected from 1687 individuals belonging to 772 households, during and after passage of the pandemic wave. Antibodies to pH1N1/2009v were titered using the hemagglutination inhibition assay (HIA) with titers ≥1/40 being considered positive. Seroprevalence during the first two weeks of detection of pH1N1/2009v in Reunion Island was 29.8% in people under 20 years of age, 35.6% in adults (20 59 years) and 73.3% in the elderly (≥60 years) (P
Conclusions. Seroincidence of pH1N1/2009v infection was three times that estimated from clinical surveillance, indicating that almost two thirds of infections occurring at the community level have escaped medical detection. People under 20 years of age were the most affected group. Pre-epidemic titers ≥1/40 prevented seroconversion and are likely protective against infection. A concern was raised about the long term stability of the antibody responses.
|
| PMID Pubmed : | Pubmed : 21980532  |
| Lien externe DOI : | DOI : 10.1371/journal.pone.0025738 |
| Corpus : | Grippe A(H1N1)/Production scientifique InVS |
| Lien(s) externe(s) : | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025738 |
| Permalink : | http://opac.invs.sante.fr/index.php?lvl=notice_display&id=9879 |
Pandemic influenza due to pH1N1/2009 virus: estimation of infection burden in Reunion Island through a prospective serosurvey, austral winter 2009 / Dellagi K in PloS one [PLoS One], Vol. 6, N° 9 ([01/09/2011])
